Pub. Date : 2016 Apr 1
PMID : 26906474
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A hydroxyethylaminopropyl side chain on the lactam nitrogen of two halogenated indenoisoquinoline Top1 inhibitors was found to also impart inhibitory activity against tyrosyl DNA phosphodiesterases 1 and 2 (TDP1 and TDP2), which are enzymes that participate in the repair of DNA damage induced by Top1 poisons. | Lactams | tyrosyl-DNA phosphodiesterase 2 | Homo sapiens |