Title : Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device.

Pub. Date : 2016 Mar 28

PMID : 26883753






1 Functional Relationships(s)
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1 In this study we present a novel two tier platform; i) a peptide delivery system, termed RALA, that is able to wrap the DNA into nanoparticles, protect the DNA from degradation, enter cells, disrupt endosomes and deliver the DNA to the nucleus of cells ii) a microneedle (MN) patch that will house the nanoparticles within the polymer matrix, breach the skin"s stratum corneum barrier and dissolve upon contact with skin interstitial fluid thus releasing the nanoparticles into the skin. Polymers RAS like proto-oncogene A Homo sapiens