Title : Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.

Pub. Date : 2016 Mar 22

PMID : 26883108






2 Functional Relationships(s)
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1 In addition, combined treatment with GSK2830371 and doxorubicin or nutlin-3 potentiated cell death through a strong induction of p53 pathway and activation of caspase 9. GSK2830371 tumor protein p53 Homo sapiens
2 We conclude that efficient inhibition of WIP1 by GSK2830371 sensitizes breast cancer cells with amplified PPM1D and wild type p53 to chemotherapy. GSK2830371 tumor protein p53 Homo sapiens