Title : Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition.

Pub. Date : 2016 Sep 15

PMID : 26876211






1 Functional Relationships(s)
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1 Co-treatment of PDAC cells with lumican and gemcitabine increased mitochondrial damage, reactive oxygen species (ROS) production and cytochrome c release, indicating that lumican-induced disruption of mitochondrial function may be the mechanism of sensitization to gemcitabine. pdac cytochrome c, somatic Homo sapiens