Title : Strain dependency of the effects of nicotine and mecamylamine in a rat model of attention.

Pub. Date : 2016 Apr

PMID : 26875755






2 Functional Relationships(s)
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1 CONCLUSIONS: The findings suggest strain differences in the attention-enhancing effects of nicotine, which would indicate that genetic predispositions predict variability in the efficacy of nAChR compounds for enhancing attention. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 The absence of effect of mecamylamine on response accuracy may suggest a contribution of nAChR desensitization to the attention-enhancing effects of nicotine. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus