Title : Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors.

Pub. Date : 2016 Aug

PMID : 26871405






2 Functional Relationships(s)
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1 The current study extended these findings by investigating whether nicotine self-administration in male, Sprague-Dawley rats (a) attenuates short-term dopaminergic damage induced by methamphetamine and (b) causes alterations in levels of alpha4beta2* and alpha6beta2* nAChR subtypes. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 The ability of nicotine to attenuate the effects of methamphetamine on DAT function corresponded with increases in alpha4beta2*, but not alpha6beta2*, nAChR binding density. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus