Title : Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy.

Pub. Date : 2016

PMID : 26870698






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 One of these molecules, APR-246, is a prodrug that is converted to the Michael acceptor methylene quinuclidinone (MQ) that binds covalently to cysteines in p53, leading to refolding and restoration of wild type p53 function. Cysteine tumor protein p53 Homo sapiens
2 One of these molecules, APR-246, is a prodrug that is converted to the Michael acceptor methylene quinuclidinone (MQ) that binds covalently to cysteines in p53, leading to refolding and restoration of wild type p53 function. Cysteine tumor protein p53 Homo sapiens