Title : Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.

Pub. Date : 2016 Jun

PMID : 26867505

1 Functional Relationships(s)
Compound Name
Protein Name
1 alpha7 nicotinic acetylcholine receptor (nAChR) antagonists mimicked the effect of nicotine and selective removal of hippocampal cholinergic input caused depotentiation in the absence of nicotine, suggesting that nicotine depotentiates consolidated LTP by inducing alpha7 nAChR desensitization. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus