Title : GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.

Pub. Date : 2016 Jun

PMID : 26850694






2 Functional Relationships(s)
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1 Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein. glyoxylic acid glutathione S-transferase zeta 1 Homo sapiens
2 Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein. glyoxylic acid glutathione S-transferase zeta 1 Homo sapiens