Title : Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro.

Pub. Date : 2016

PMID : 26848974






7 Functional Relationships(s)
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1 Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
2 However, proximal signaling events that result in nephrin tyrosine phosphorylation are not well understood. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
3 Nephrin is tyrosine phosphorylation-silent in healthy glomeruli when presumably the nephrin extracellular domain is in an engaged state. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
4 These observations raise the possibility of an alternate proximal signaling mechanism that might be responsible for nephrin tyrosine phosphorylation. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
5 Here we present data showing that integrin engagement at the basal aspect of cultured podocytes results in nephrin tyrosine phosphorylation. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
6 Furthermore, nephrin tyrosine phosphorylation was observed in podocytes expressing a membrane-targeted nephrin construct that lacks the extracellular domain. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens
7 Furthermore, nephrin tyrosine phosphorylation was observed in podocytes expressing a membrane-targeted nephrin construct that lacks the extracellular domain. Tyrosine NPHS1 adhesion molecule, nephrin Homo sapiens