Title : Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study.

Pub. Date : 2016 Jun

PMID : 26846333






2 Functional Relationships(s)
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1 BACKGROUND: Roxadustat (FG-4592) is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin. roxadustat hepcidin antimicrobial peptide Homo sapiens
2 Hepcidin level reduction was greater at roxadustat 2.0mg/kg versus epoetin alfa (P<0.05). roxadustat hepcidin antimicrobial peptide Homo sapiens