Title : Profilin potentiates chemotherapeutic agents mediated cell death via suppression of NF-κB and upregulation of p53.

Pub. Date : 2016 Apr

PMID : 26842845






1 Functional Relationships(s)
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1 This inhibition was due to the Profilin mediated attenuation of IkappaBalpha degradation, thereby preventing p65 nuclear translocation and low NF-kappaB DNA binding activity.Moreover, Profilin increases level of p53 in the presence of known inducers, such as doxorubicin, vinblastine, and benzofuran. benzofuran tumor protein p53 Homo sapiens