Pub. Date : 2016 Feb
PMID : 26838733
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Electrophysiological experiments revealed that tacrolimus (10 micromol/L) increased the large-conductance Ca(2+)-activated K(+) currents (BKCa) in rat aortic vascular smooth muscle cells (AVSMCs), which could be blocked by ryanodine (10 micromol/L). | Tacrolimus | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |
| 2 | In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca(2+) sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta. | Tacrolimus | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |