Title : Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells.

Pub. Date : 2016 Apr 15

PMID : 26830534






1 Functional Relationships(s)
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1 The mechanism likely involves inhibition of catalase activity by nitrite (IC50, 9 muM), which allows H2O2 to accumulate and oxidize Cys moieties of oxyhemoglobin and erythrocytic GSH to form HbSSG in addition to GSSG. Glutathione latexin Homo sapiens