Pub. Date : 2016 Jan 27
PMID : 26818499
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of ATP13A2 via PHD2-HIF1alpha Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson"s Disease. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 2 | Knockdown of ATP13A2 expression within human DAergic cells was found to abrogate restoration of cellular iron homeostasis and neuronal cell viability elicited by inhibition of PHD2 under conditions of mitochondrial stress, likely via effects on lysosomal iron storage. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 3 | Knockdown of ATP13A2 expression within human DAergic cells was found to abrogate restoration of cellular iron homeostasis and neuronal cell viability elicited by inhibition of PHD2 under conditions of mitochondrial stress, likely via effects on lysosomal iron storage. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 4 | These data suggest that regulation of ATP13A2 by the PHD2-HIF1alpha signaling pathway affects cellular iron homeostasis and DAergic neuronal survival. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 5 | Knockdown of ATP13A2, a gene linked to a rare juvenile form of Parkinson"s disease and recently identified as a novel HIF1alpha target, was found to abrogate maintenance of cellular iron homeostasis and neuronal viability elicited by PHD2 inhibition in vivo and in cultured dopaminergic cells under conditions of mitochondrial stress. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 6 | Mechanistically, this was due to ATP13A2"s role in maintaining lysosomal iron stores. | Iron | ATPase cation transporting 13A2 | Homo sapiens |