Title : Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.

Pub. Date : 2015 Oct 13

PMID : 26815242






1 Functional Relationships(s)
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1 Here we show, by inactivating the immunoglobulin tail tyrosine (ITT) signalling motif of membrane-bound IgG1 in the mouse, that the ITT facilitates maintenance and reactivation of IgG-switched memory B cells in vivo. Inosine Triphosphate immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus