Title : Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes.

Pub. Date : 2016 May

PMID : 26811540






3 Functional Relationships(s)
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1 Moreover, IL-1beta-induced FGF-2 expression via IL-1RI (type-1 IL-1 receptor), ROS (reactive oxygen species) generation, AMPK (AMP-activated protein kinase), p38 and NF-kappaB (nuclear factor kappaB) pathway has been demonstrated. Reactive Oxygen Species interleukin 1 beta Mus musculus
2 Moreover, IL-1beta-induced FGF-2 expression via IL-1RI (type-1 IL-1 receptor), ROS (reactive oxygen species) generation, AMPK (AMP-activated protein kinase), p38 and NF-kappaB (nuclear factor kappaB) pathway has been demonstrated. Reactive Oxygen Species interleukin 1 beta Mus musculus
3 On the basis of these findings, we conclude that IL-1beta promotes FGF-2 expression in chondrocytes through the ROS/AMPK/p38/NF-kappaB signalling pathway and subsequently increases EPC angiogenesis. Reactive Oxygen Species interleukin 1 beta Mus musculus