Title : Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis.

Pub. Date : 2016 Apr

PMID : 26805387






1 Functional Relationships(s)
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1 Cell culture and metabolic flux experiments, showing enhanced expression of desaturases (FADS2) and beta-oxidation enzymes after H2O2 challenge suggest that DHA production can be an initial response to oxidative stress, driven by TDP-43 aggregation and drebrin loss. Hydrogen Peroxide drebrin 1 Homo sapiens