Pub. Date : 2016 Feb 16
PMID : 26799187
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | These results suggest for the first time that the p38 MAPK/p53/EGFR axis is crucial for the facilitation of PTX resistance in NSCLCs. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | These results provide a foundation for the future development of potential therapeutic strategies to regulate the p38 MAPK/p53/EGFR pathway for the treatment of lung cancer patients with PTX resistance. | Paclitaxel | tumor protein p53 | Homo sapiens |