Title : Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition.

Pub. Date : 2015

PMID : 26793111






2 Functional Relationships(s)
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1 In addition, treatment with celastrol inhibited inflammatory responses, as indicated by the decrease of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, down-regulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and inactivation of nuclear factor kappaB (NF-kappaB). celastrol nitric oxide synthase 2, inducible Mus musculus
2 In addition, treatment with celastrol inhibited inflammatory responses, as indicated by the decrease of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, down-regulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and inactivation of nuclear factor kappaB (NF-kappaB). celastrol nitric oxide synthase 2, inducible Mus musculus