Pub. Date : 2016 Feb 15
PMID : 26773156
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 2 | C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 3 | In this study, we explored whether C1q deficiency could affect pristane-induced lupus. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 4 | In keeping with the clinical scores, 2 wk after pristane injection the peritoneal recruitment of CD11b(+) Ly6C(high) inflammatory monocytes in C1qa(-/-) mice was impaired. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 5 | Furthermore, C1q-deficient pristane-primed resident peritoneal macrophages secreted significantly less CCL3, CCL2, CXCL1, and IL-6 when stimulated in vitro with TLR7 ligand. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 6 | Replenishing C1q in vivo during the pristane-priming phase rectified this defect. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 7 | These findings demonstrate that C1q deficiency impairs the TLR7-dependent chemokine production by pristane-primed peritoneal macrophages and suggest that C1q, and not C3, is involved in the handling of pristane by phagocytic cells, which is required to trigger disease in this model. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 8 | These findings demonstrate that C1q deficiency impairs the TLR7-dependent chemokine production by pristane-primed peritoneal macrophages and suggest that C1q, and not C3, is involved in the handling of pristane by phagocytic cells, which is required to trigger disease in this model. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 9 | These findings demonstrate that C1q deficiency impairs the TLR7-dependent chemokine production by pristane-primed peritoneal macrophages and suggest that C1q, and not C3, is involved in the handling of pristane by phagocytic cells, which is required to trigger disease in this model. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |
| 10 | These findings demonstrate that C1q deficiency impairs the TLR7-dependent chemokine production by pristane-primed peritoneal macrophages and suggest that C1q, and not C3, is involved in the handling of pristane by phagocytic cells, which is required to trigger disease in this model. | pristane | complement component 1, q subcomponent, alpha polypeptide | Mus musculus |