Title : MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.

Pub. Date : 2016 Feb 9

PMID : 26769852






2 Functional Relationships(s)
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1 Sorafenib-resistant cell lines were established from the HCC cell line PLC/PRF5 by cultivation under continuous exposure to increasing concentration of sorafenib. Sorafenib heparan sulfate proteoglycan 2 Homo sapiens
2 When MRP3 gene was knocked down by siRNA in PLC-PRF5-R2 cells, the sensitivity of the cells to sorafenib was restored. Sorafenib heparan sulfate proteoglycan 2 Homo sapiens