Title : miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells.

Pub. Date : 2016 Feb 5

PMID : 26768586






2 Functional Relationships(s)
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1 Over-expression of NOX4 or p66(shc) suppressed the inhibitory effects of GB on superoxide generation and the protective effects of GB on loss of cell viability and apoptosis associated with cisplatin. Superoxides DNA polymerase delta 3, accessory subunit Homo sapiens
2 We demonstrate that GB decreases superoxide generation and the subsequent apoptosis through reduction of p53-mediated NOX4/p66(shc) pathway via up-regulation of miR214, resulting in attenuation of cisplatin-induced cytotoxicity. Superoxides DNA polymerase delta 3, accessory subunit Homo sapiens