Title : Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine.

Pub. Date : 2016 Mar

PMID : 26763728






1 Functional Relationships(s)
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1 Moreover, in rats exposed to a single intrathecal administration of IL-18BP (50 and 100 ng) 7 or 14 days following CCI, symptoms of neuropathic pain were attenuated, and the analgesia pursuant to morphine and buprenorphine (0.5 and 2.5 mug) was enhanced. Buprenorphine interleukin 18 binding protein Rattus norvegicus