Title : A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Pub. Date : 2016 Jan 13

PMID : 26757638






3 Functional Relationships(s)
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Protein Name
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1 Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. Reactive Oxygen Species pyruvate carboxylase Homo sapiens
2 Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. Reactive Oxygen Species pyruvate carboxylase Homo sapiens
3 These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD. Reactive Oxygen Species pyruvate carboxylase Homo sapiens