Title : Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.

Pub. Date : 2016 Feb 9

PMID : 26749241






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain. Iron heat shock protein family A (Hsp70) member 9 Homo sapiens