Title : Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts.

Pub. Date : 2016 Feb

PMID : 26744072






4 Functional Relationships(s)
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1 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost mitogen-activated protein kinase 14 Mus musculus
2 We previously reported that prostaglandin F2alpha (PGF2alpha) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. Dinoprost mitogen-activated protein kinase 14 Mus musculus
3 We have also demonstrated that PGF2alpha induced the synthesis of interleukin-6 (IL-6) via p38 MAP kinase and p44/p42 MAP kinase but not SAPK/JNK in these cells. Dinoprost mitogen-activated protein kinase 14 Mus musculus
4 The phosphorylation of p38 MAP kinase, p44/p42 MAP kinase or SAPK/JNK induced by PGF2alpha was not markedly affected by either mimosine or deferoxamine. Dinoprost mitogen-activated protein kinase 14 Mus musculus