Title : NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis.

Pub. Date : 2016 Jan 6

PMID : 26733361






3 Functional Relationships(s)
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1 A novel transduction pathway for the powerful angiogenic factor VEGF has been recently shown in endothelial cells to operate through NAADP-controlled intracellular release of Ca(2+). NAADP vascular endothelial growth factor A Mus musculus
2 In the present report the possible involvement of NAADP-controlled Ca(2+) signaling in tumor vascularization, growth and metastatic dissemination was investigated in a murine model of VEGF-secreting melanoma. NAADP vascular endothelial growth factor A Mus musculus
3 To this regard, Ca(2+) imaging experiments showed that the response of B16 cells to VEGF stimulation is NAADP-dependent. NAADP vascular endothelial growth factor A Mus musculus