Title : 2-Methoxyestradiol, an endogenous 17β-estradiol metabolite, inhibits microglial proliferation and activation via an estrogen receptor-independent mechanism.

Pub. Date : 2016 Mar 1

PMID : 26732685






1 Functional Relationships(s)
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1 The antiproliferative effects of estradiol, but not 2-OE or 2-ME, were partially reversed by ICI-182,780 (ERalpha/beta antagonist) but not by 1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole (ERalpha antagonist) or G15 (GPR30 antagonist). Estradiol G protein-coupled estrogen receptor 1 Mus musculus