Title : A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture.

Pub. Date : 2016 Jan 4

PMID : 26727576






1 Functional Relationships(s)
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1 In ABC DLBCL cells, eosinophils and perhaps all cells, four variant STAT3 mRNAs (Salpha, DeltaSalpha, Sbeta and DeltaSbeta) are present as a result of two alternative splicing events, one that results in the inclusion of a 55-residue C-terminal transactivation domain (alpha) or a truncated C-terminal domain with 7 unique residues (beta) and a second that includes (S) or excludes (DeltaS) the codon for Ser-701 in the linker between the SH2 and C-terminal domains. Serine signal transducer and activator of transcription 3 Homo sapiens