Title : Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Pub. Date : 2015 Dec 10

PMID : 26713112






1 Functional Relationships(s)
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1 By recognizing that the limitations of FRAX1036 (1) were chiefly associated with the highly basic amine it contained, we devised a mitigation strategy to address several issues such as hERG activity. Amines ETS transcription factor ERG Homo sapiens