Title : ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.

Pub. Date : 2015 Dec 29

PMID : 26711340






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Such rapid H2AX stabilization by DSBs was associated with chromatin incorporation of H2AX and halting of its poly-ubiquitination mediated by the ATM kinase, the sirtuin protein SIRT6, and the chromatin remodeler SNF2H. dsbs SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Homo sapiens