Title : Specific Conjugation of the Hinge Region for Homogeneous Preparation of Antibody Fragment-Drug Conjugate: A Case Study for Doxorubicin-PEG-anti-CD20 Fab' Synthesis.

Pub. Date : 2016 Jan 20

PMID : 26700095






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The model drug doxorubicin (DOX) was coupled to the Fab" fragment of anti-CD20 IgG at its permissive sites through a heterotelechelic PEG linker, generating an antibody fragment-drug conjugate (AFDC). Doxorubicin FA complementation group B Homo sapiens
2 The model drug doxorubicin (DOX) was coupled to the Fab" fragment of anti-CD20 IgG at its permissive sites through a heterotelechelic PEG linker, generating an antibody fragment-drug conjugate (AFDC). Doxorubicin FA complementation group B Homo sapiens