Title : Reduced sulfotransferase SULT2A1 activity in patients with Alzheimer's disease.

Pub. Date : 2015

PMID : 26680489






2 Functional Relationships(s)
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1 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids sulfotransferase family 2A member 1 Homo sapiens
2 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids sulfotransferase family 2A member 1 Homo sapiens