Pub. Date : 2015 Dec 14
PMID : 26678339
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | To identify other metabolic therapeutic targets, we systematically profiled metabolites in endogenous IDH1 mutant cancer cells after mutant IDH1 inhibition and discovered a profound vulnerability to depletion of the coenzyme NAD+. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 6 | Thus, we identify NAD+ depletion as a metabolic susceptibility of IDH1 mutant cancers. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |