Title : Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.

Pub. Date : 2016 Jan 1

PMID : 26678173






1 Functional Relationships(s)
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1 We here experimentally demonstrate the high systemic potential of the synthetically-accessible, phosphodiester-linked monovalent GalNAc unit when tethered to the 5"-terminus of well-characterised 2",4"-bridged nucleic acid (also known as locked nucleic acid)-modified apolipoprotein B-targeting ASO via a bio-labile linker. N-acetylgalactosaminuronic acid apolipoprotein B Homo sapiens