Title : Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation.

Pub. Date : 2016 Feb

PMID : 26671842






4 Functional Relationships(s)
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1 After a 72 h treatment with 150 muM DHA and EPA, or their combination (75/75 muM), growth rates were inhibited by 80.3 +- 5.5%, 79.3 +- 5% and 71.1 +- 1%, respectively, compared to untreated cells. Docosahexaenoic Acids latexin Homo sapiens
2 After a 72 h treatment with 150 muM DHA and EPA, or their combination (75/75 muM), growth rates were inhibited by 80.3 +- 5.5%, 79.3 +- 5% and 71.1 +- 1%, respectively, compared to untreated cells. Docosahexaenoic Acids latexin Homo sapiens
3 We also found that treatment for 48 h with 100 muM DHA and EPA, or their combination (50/50 muM), resulted in 2.9-, 3- and 2.6-fold increases in caspase-3 activation, as well as 54, 62.4 and 100% decreases in survivin mRNA expression levels, respectively, compared to untreated cells. Docosahexaenoic Acids latexin Homo sapiens
4 We also found that treatment for 48 h with 100 muM DHA and EPA, or their combination (50/50 muM), resulted in 2.9-, 3- and 2.6-fold increases in caspase-3 activation, as well as 54, 62.4 and 100% decreases in survivin mRNA expression levels, respectively, compared to untreated cells. Docosahexaenoic Acids latexin Homo sapiens