Title : Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis.

Pub. Date : 2016 Jan 22

PMID : 26660433






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 BBOX contains an aromatic cage for the recognition of the positively charged trimethylammonium group of the gammaBB substrate. Cetrimonium gamma-butyrobetaine hydroxylase 1 Homo sapiens
2 Enzyme binding and kinetic analyses on substrate analogues with P and As substituting for N in the trimethylammonium group show that the analogues are good BBOX substrates, which follow the efficiency trend N(+) >P(+) >As(+). Cetrimonium gamma-butyrobetaine hydroxylase 1 Homo sapiens