Title : Atom based 3D-QSAR studies on 2,4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase.

Pub. Date : 2016 Feb 15

PMID : 26658266






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The reported experimental results by Piomelli and co-workers on the inhibition of aCDase by the carmofur derivatives were correlated using robust 3D-QSAR as well as docking methods. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens
2 In the present report, we have utilized atom-based 3D-QSAR method to analyze the structural aspects on a series of 2,4-dioxopyrimidine-1-carboxamide (carmofur) derivatives as potent inhibitors of aCDase. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens