Pub. Date : 2016 Feb 28
PMID : 26655273
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our miRNA microarray data indicate that liver-specific miR-122 expression was significantly reduced in sorafenib-resistant cells. | Sorafenib | microRNA 122 | Homo sapiens |
| 2 | Overexpression of miR-122 made drug-tolerant cells sensitive to sorafenib and induced apoptosis. | Sorafenib | microRNA 122 | Homo sapiens |
| 3 | These results indicated that activation of IGF-1R by ectopic down-regulation of miR-122 counteracted the effects of sorafenib-induced apoptosis, thus conferring sorafenib resistance. | Sorafenib | microRNA 122 | Homo sapiens |
| 4 | These results indicated that activation of IGF-1R by ectopic down-regulation of miR-122 counteracted the effects of sorafenib-induced apoptosis, thus conferring sorafenib resistance. | Sorafenib | microRNA 122 | Homo sapiens |
| 5 | Our data imply that an intimate correlation between miR-122 and IGF-1R abnormal expression is a critical determinant of sorafenib tolerance. | Sorafenib | microRNA 122 | Homo sapiens |