Title : Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model.

Pub. Date : 2016 Apr 10

PMID : 26649526






2 Functional Relationships(s)
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1 INNOVATION: The present study demonstrates the critical role of GSH/GSSG imbalance-mediated ROS production contributing to the STAT3 inhibitory and tumor-suppressive effect of NL in PCa. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus
2 CONCLUSION: Overall, our findings indicate that NL exhibits significant anticancer effects in PCa that may be primarily mediated through the ROS-regulated inhibition of STAT3 signaling cascade. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus