Title : DOWN-REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY INOSITOL HEXAPHOSPHATE IN HUMAN COLON CANCER CELLS.

Pub. Date : 2015 Jul-Aug

PMID : 26647627






4 Functional Relationships(s)
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1 In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated. Phytic Acid interleukin 1 beta Homo sapiens
2 In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated. Phytic Acid interleukin 1 beta Homo sapiens
3 Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined. Phytic Acid interleukin 1 beta Homo sapiens
4 Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined. Phytic Acid interleukin 1 beta Homo sapiens