Title : Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

Pub. Date : 2015

PMID : 26641266






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1 Furthermore, we found that metformin alleviates tumor inflammation by reducing the expression of inflammatory cytokines including IL-1beta as well as infiltration and M2 polarization of tumor-associated macrophages (TAMs) in vitro and in vivo. Metformin interleukin 1 beta Homo sapiens