Title : A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Pub. Date : 2015 Dec 3

PMID : 26634245






1 Functional Relationships(s)
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1 RESULTS: Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (lowest p-value = 2.17 x 10(-11)), and FEV1/FVC was associated with a genomic region on chromosome 4 [upstream of HHIP] (lowest p-value = 5.94 x 10(-10)); both regions have been previously associated with COPD. copdgene hydroxylysine kinase Homo sapiens