Title : Sodium Fluoride Affects DNA Methylation of Imprinted Genes in Mouse Early Embryos.

Pub. Date : 2015

PMID : 26633825






3 Functional Relationships(s)
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1 It was shown that the H19 gene was significantly downmethylated in E2.5, E3.5, and E4.5 embryos from pregnant mice treated with 120 mg/l NaF in drinking water for 48 h. But methylation of both H19 and Peg3 genes was disrupted when the parent male mice were treated with NaF for 35 days. Sodium Fluoride paternally expressed 3 Mus musculus
2 However, when pregnant mice, mated with NaF-treated male mice, were again treated with NaF for 48 h, either H19 or Peg3 methylation in the embryos decreased significantly. Sodium Fluoride paternally expressed 3 Mus musculus
3 However, when pregnant mice, mated with NaF-treated male mice, were again treated with NaF for 48 h, either H19 or Peg3 methylation in the embryos decreased significantly. Sodium Fluoride paternally expressed 3 Mus musculus