Pub. Date : 2015 Dec 29
PMID : 26625311
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1alpha/VEGF secretion axis. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 2 | Furthermore, our results of VEGF-neutralizing and -rescuing tests showed that metformin markedly abrogated HER2 signaling-induced tumor angiogenesis by inhibiting VEGF secretion. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 3 | Furthermore, our results of VEGF-neutralizing and -rescuing tests showed that metformin markedly abrogated HER2 signaling-induced tumor angiogenesis by inhibiting VEGF secretion. | Metformin | vascular endothelial growth factor A | Homo sapiens |
| 4 | Our data thus provides novel insight into the mechanism underlying the metformin-induced inhibition of tumor angiogenesis and indicates possibilities of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis. | Metformin | vascular endothelial growth factor A | Homo sapiens |