Title : Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.

Pub. Date : 2015 Dec 24

PMID : 26613420






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The X-ray crystal structure of 5b in complex with VDR reveals that the ligand binds similarly to the natural hormone, but the diyne moiety is slightly bent (angles around the diyne 5 to 8 ) with respect to the original diyne vitamin D compound 6 in VDR (<1 ) due to steric hindrance with helix 12. Diynes vitamin D receptor Homo sapiens
2 The X-ray crystal structure of 5b in complex with VDR reveals that the ligand binds similarly to the natural hormone, but the diyne moiety is slightly bent (angles around the diyne 5 to 8 ) with respect to the original diyne vitamin D compound 6 in VDR (<1 ) due to steric hindrance with helix 12. Diynes vitamin D receptor Homo sapiens