Title : Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress.

Pub. Date : 2016 Mar

PMID : 26609913






1 Functional Relationships(s)
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1 To study the mechanism, we found that costunolide exposure activated the unfolded protein response (UPR) signaling pathways, as shown by the up-regulation of GRP78 and IRE1alpha and the activation of ASK1 and JNK. costunolide heat shock protein family A (Hsp70) member 5 Homo sapiens