Pub. Date : 2015
PMID : 26609525
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 2 | We explored whether isoflurane damaged developing hippocampi through FASL-FAS signaling pathway, which is a well-known pathway of apoptosis. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 3 | Isoflurane increased expression of FAS and FASL proteins in wild type mice. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 4 | Compared to isoflurane-treated FAS- and FASL-knockout mice, isoflurane-treated wild type mice had higher expression of caspase-3 and more TUNEL-positive hippocampal cells. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 5 | Expression of caspase-3 in wild isoflurane group, wild control group, FAS/FASL-gene-knockout control group, and FAS/FASL-gene-knockout isoflurane group showed FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 6 | Expression of caspase-3 in wild isoflurane group, wild control group, FAS/FASL-gene-knockout control group, and FAS/FASL-gene-knockout isoflurane group showed FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 7 | Expression of caspase-3 in wild isoflurane group, wild control group, FAS/FASL-gene-knockout control group, and FAS/FASL-gene-knockout isoflurane group showed FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 8 | Expression of caspase-3 in wild isoflurane group, wild control group, FAS/FASL-gene-knockout control group, and FAS/FASL-gene-knockout isoflurane group showed FAS or FASL gene knockout might attenuate increase of caspase-3 caused by isoflurane. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |
| 9 | Isoflurane induces apoptosis in developing hippocampi of wild type mice but not in FAS- and FASL-knockout mice and damages brain development through FASL-FAS signaling. | Isoflurane | Fas ligand (TNF superfamily, member 6) | Mus musculus |