Pub. Date : 2016 Jan
PMID : 26582371
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
2 | Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
3 | Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
4 | We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
5 | We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
6 | We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
7 | To test this hypothesis, we investigated the effects of pre-treatment of rats with recombinant-hepcidin-adenovirus (ad-hepcidin) on the contents of iron, dichlorofluorescein and 8-isoprostane in the brain. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
8 | We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
9 | We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |