Title : Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain.

Pub. Date : 2016 Jan

PMID : 26582371






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1 Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain. Iron hepcidin antimicrobial peptide Rattus norvegicus
2 Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins. Iron hepcidin antimicrobial peptide Rattus norvegicus
3 Our recent investigation showed that hepcidin can reduce iron in the brain of iron-overloaded rat by down-regulating iron-transport proteins. Iron hepcidin antimicrobial peptide Rattus norvegicus
4 We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. Iron hepcidin antimicrobial peptide Rattus norvegicus
5 We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. Iron hepcidin antimicrobial peptide Rattus norvegicus
6 We therefore hypothesized that hepcidin could prevent iron accumulation and thus reduce iron-mediated oxidative stress in iron-overloaded rats. Iron hepcidin antimicrobial peptide Rattus norvegicus
7 To test this hypothesis, we investigated the effects of pre-treatment of rats with recombinant-hepcidin-adenovirus (ad-hepcidin) on the contents of iron, dichlorofluorescein and 8-isoprostane in the brain. Iron hepcidin antimicrobial peptide Rattus norvegicus
8 We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats. Iron hepcidin antimicrobial peptide Rattus norvegicus
9 We concluded that pre-treatment with ad-hepcidin could increase hepcidin expression and prevent the increase in iron and reduce reactive oxygen species in the brain of iron-overloaded rats. Iron hepcidin antimicrobial peptide Rattus norvegicus